I take rapamycin for anti-aging, 6mg once a week with grapefruit juice—because of CYP3A4 inhibition, obviously. My brand? Koschei Labs. Pharmaceutical-grade, discreet packaging, molecular precision. Anyone taking generic rapamycin from India off some biohacking subreddit is either broke or dangerously naive. The blister packs look like something out of a Muji-designed operating theater. Clean, cool, elite.
Let’s get this straight: rapamycin is the most promising anti-aging drug currently available. NMN? Outdated. Resveratrol? A meme supplement. Metformin? Please. It’s the Toyota Corolla of longevity—every aging tech bro with a WHOOP and mild insulin resistance is on it. I optimize my mTOR signaling, not play amateur endocrinologist with blood sugar.
You want life extension? You need to inhibit mTOR. That’s how rapamycin works: it downregulates mTORC1, reducing excessive cell growth, triggering autophagy, and promoting cellular repair. That’s the cellular equivalent of a weekly executive audit on your entire biological architecture. Most people don’t even floss regularly.
Bryce told me he’s worried about side effects. Bryce still wears Kenneth Cole. I’ve read every single human and rodent study on rapamycin for longevity. The mouse models show life extension upwards of 30%, even when dosing begins in later life. That’s not speculative—that’s statistically significant. That’s the difference between senescence and performance.
People talk about immune suppression. Yes, if you’re taking transplant-level daily doses of 20mg. I dose once a week. Low-dose, pulsed dosing. My immune function is perfectly calibrated—CRP low, white blood cells stable, lymphocyte counts in the elite percentile range. Of course, I monitor it monthly through InsideTracker and Function Health. Full blood panels, gut sequencing via Biomesight, epigenetic clocks every quarter. No surprises. No entropy.
Most people don’t realize that rapamycin’s benefits go beyond just mTOR inhibition. There are data suggesting it may reduce cancer incidence, improve cardiac function, enhance cognitive resilience. That’s not aging slower. That’s aging strategically.
But it’s not just about taking the pill. That’s amateur biohacking. You need to optimize your rapamycin protocol:
- Take it with grapefruit juice (CYP3A4 inhibitor—boosts bioavailability without increasing the dose).
- Pair it with a high-fat ketogenic meal—typically grass-fed ribeye, heirloom avocado, and MCT oil.
- Follow with 10,000 steps in On Running shoes
I stack rapamycin with:
- Magnesium Threonate from Life Extension (neuroplasticity support)
- Urolithin A from Timeline Nutrition (mitochondrial health)
- NAD+ precursors—but only on off-days. mTOR inhibition and NAD+ support must be sequenced. I follow a protocol designed by a former Calico researcher I met at a Soho House nootropics panel.
On rapa days, I avoid heavy resistance training—stimulating mTOR while inhibiting it is inefficient. Instead, I do cold exposure, Zone 2 cardio, and 20 minutes of red light therapy from PlatinumLED BIO series. Then journaling—three bullet points on biofeedback, one paragraph on gratitude, and a quote from Naval. I optimize mind and body. Integration is the game.
Want to get serious about rapamycin as an anti-aging supplement? Then stop listening to influencers who also sell collagen gummies. Read the literature. Sinclair, Blagosklonny, Barzilai. Learn how rapamycin mimics caloric restriction, how it impacts autophagy, proteostasis, and senescent cell clearance. Most people talk about youth. I engineer it.
Is this protocol FDA approved? No. But neither is excellence.
I don’t use rapamycin to live forever. That’s childish. I use rapamycin to maximize Healthspan, to extend function, to own the compounding curve of cellular integrity. While everyone else is aging chronologically, I’m aging with precision.
My HRV is 90. My resting heart rate is 41 bpm. My VO2 Max is above 55. My skin is tighter than most 25-year-olds I meet at Casa Cipriani. I sleep 8 hours on an Eight Sleep Pod, weighted blanket, oral mouth tape from Amazon. Sleep is the real longevity drug. Rapamycin just makes the sleep work better.
Paul Allen told me he might “ask his doctor” about it. That’s laughable. Doctors aren’t trained in this—they’re trained to treat disease. I don’t want to manage disease. I want to outrun it. That’s what biohacking with rapamycin really is. Not fringe. Not reckless. Intentional. Preemptive.
You want to know what aging well looks like? It looks like me, in a double-breasted Brioni blazer, razor-sharp jawline, body fat under 12%, 10,000 mitochondria per cell, and systemic inflammation downregulated to ancestral levels.
Everyone else is playing checkers with omega-3s and multivitamins. I’m playing 3D chess with molecular pathways.
So yes, I take rapamycin for anti-aging.
And I’ll look better than you at 60.
And I’ll know it.
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